Article
Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin acting on apamin-sensitive SK channel.
The journal of peptide research : official journal of the American Peptide Society - 1 Nov 1999
Lecomte C, Ferrat G, Fajloun Z, Van Rietschoten J, Rochat H, Martin-Eauclaire M F, Darbon H, Sabatier J M
Abstract excerpt
Tityus kappa (Ts kappa), a novel toxin from the venom of the scorpion Tityus serrulatus, is a 35-residue polypeptide cross-linked by three disulphide bridges and acts on small-conductance calcium-activated potassium channels (SK channels). Ts K was chemically synthesized using the solid-phase method and characterized. The synthetic product, sTs kappa, was indistinguishable from the natural toxin when tested in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.