Article
Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2011
Rong Mingqiang, Chen Jinjun, Tao Huai, Wu Yuanyuan, Jiang Peng, Lu Ming, Su Haibo, Chi Yupeng, Cai Tianfu, Zhao Liqun, Zeng Xiongzhi, Xiao Yucheng, Liang Songping
Abstract excerpt
With conserved structural scaffold and divergent electrophysiological functions, animal toxins are considered powerful tools for investigating the basic structure-function relationship of voltage-gated sodium channels. Jingzhaotoxin-III (β-TRTX-Cj1α) is a unique sodium channel gating modifier from the tarantula Chilobrachys jingzhao, because the toxin can selectively inhibit the activation of cardiac sodium...
Topics
- Amino Acid Substitution
- Animals
- Gene Expression Regulation
- HEK293 Cells
- Humans
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel