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Article

The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor.

The Journal of biological chemistry - 3 Jun 2005

Thomas Monzy, Yu Zhigang, Dadgar Nahid, Varambally Sooryanarayana, Yu Jianjun, Chinnaiyan Arul M, Lieberman Andrew P

Abstract excerpt

Kennedy disease, a degenerative disorder caused by an expanded glutamine tract, is mediated by misfolding of the mutant androgen receptor (AR) protein, a process that may disrupt proteasome function. We hypothesized that this might lead to endoplasmic reticulum (ER) stress and induction of the unfolded protein response (UPR), a complex physiologic pathway that regulates cell survival. To test this hypothesis, we...

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PMID: 15799970
DOI: 10.1074/jbc.M500144200

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ATF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor.PMID 15799970Read ↗

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