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Article

Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation.

The Journal of biological chemistry - 7 Aug 2009

Mukherjee Sarmistha, Thomas Monzy, Dadgar Nahid, Lieberman Andrew P, Iñiguez-Lluhí Jorge A

Abstract excerpt

The neurodegenerative disorder spinal and bulbar muscular atrophy or Kennedy disease is caused by a CAG trinucleotide repeat expansion within the androgen receptor (AR) gene. The resulting expanded polyglutamine tract in the N-terminal region of the receptor renders AR prone to ligand-dependent misfolding and formation of oligomers and aggregates that are linked to neuronal toxicity. How AR misfolding is...

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Identifiers

PMID: 19497852
DOI: 10.1074/jbc.M109.011494
PMCID: PMC2755854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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