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Article

Characterization of an Expanded Glutamine Repeat Androgen Receptor in a Neuronal Cell Culture System

1 Jan 1997

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an inherited form of lower motor neuron degeneration caused by expansion of a CAG repeat in the androgen receptor (AR) gene. To study the mechanism by which this mutation causes neuronal pathology, we stably transfected a motor neuron hybrid cell line with human AR cDNAs containing either 24 or 65 repeats (AR24 and AR65, respectively). Both forms of receptor were able...

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Identifiers

PMID: 9173928
DOI: 10.1006/nbdi.1997.0126

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Characterization of an Expanded Glutamine Repeat Androgen Receptor in a Neuronal Cell Culture SystemPMID 9173928Read ↗

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