Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.

Journal of Alzheimer's disease : JAD - 1 Jun 2008

Lieberman Andrew P, Robins Diane M

Abstract excerpt

The androgen receptor (AR) is a ligand-activated transcription factor that is central to androgen-dependent development and diseases. Activity of the receptor is influenced by the length of a CAG/glutamine tract in its N-terminal transactivating domain. Expansions of this tract cause Kennedy disease, a protein aggregation degenerative disorder of motor neurons that occurs only in men, and shorter length tracts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Targeting
Share to Glutamine
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Spinal Cord

Share to Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 18560135
DOI: 10.3233/jad-2008-14212
PMCID: PMC2631577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.PMID 18560135Read ↗

Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice.Semantic proximity Read ↗

Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model.Semantic proximity Read ↗

Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice.Semantic proximity Read ↗

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.Semantic proximity Read ↗

Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein.Semantic proximity Read ↗

Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.Semantic proximity Read ↗

Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Molecular Mechanisms and Therapeutics for SBMA/Kennedy's DiseaseSemantic proximity Read ↗

Androgen receptor mutation in Kennedy's disease.Semantic proximity Read ↗

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.Semantic proximity Read ↗

Structural and functional consequences of glutamine tract variation in the androgen receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.