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Article

Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model.

The Journal of clinical investigation - 1 Oct 2006

Yu Zhigang, Dadgar Nahid, Albertelli Megan, Gruis Kirsten, Jordan Cynthia, Robins Diane M, Lieberman Andrew P

Abstract excerpt

Kennedy disease, a degenerative disorder characterized by androgen-dependent neuromuscular weakness, is caused by a CAG/glutamine tract expansion in the androgen receptor (Ar) gene. We developed a mouse model of Kennedy disease, using gene targeting to convert mouse androgen receptor (AR) to human sequence while introducing 113 glutamines. AR113Q mice developed hormone and glutamine length-dependent neuromuscular...

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Source

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Identifiers

PMID: 16981011
DOI: 10.1172/JCI28773
PMCID: PMC1564432

Genes

CLCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model.PMID 16981011Read ↗

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