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Article

Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat.

Experimental neurology - 1 Dec 2007

Ng Hiushan, Pulst Stefan-M, Huynh Duong P

Abstract excerpt

Spinocerebellar ataxia 2 (SCA2) belongs to the group of neurodegenerative diseases caused by expansion of a polyglutamine (polyQ) domain. Overexpression of mutant ataxin-2 causes cell death and Golgi dispersion in cell culture as well as morphologic and functional changes in mouse models. To further define the mechanism of ataxin-2 induced cell death, we compared the cytotoxic effects of different domains of...

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Identifiers

PMID: 17949716
DOI: 10.1016/j.expneurol.2007.07.023
PMCID: PMC2186298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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