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Article

Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

The Journal of biological chemistry - 9 May 2008

Pratt Gregory, Rechsteiner Martin

Abstract excerpt

Eukaryotic proteasomes have been reported to cleave only once within polyglutamine tracts and then only after the N-terminal glutamine (Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N., and Goldberg, A. L. (2004) Mol. Cell 14, 95-104). We have obtained results that directly conflict with that report. In the presence of the proteasome activator PA28gamma(K188E) human red cell proteasomes progressively degraded...

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Identifiers

PMID: 18343811
DOI: 10.1074/jbc.M709347200
PMCID: PMC2442343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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