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Article

Specific N-terminal mutations in the human androgen receptor induce cytotoxicity.

Neurobiology of aging - 1 Nov 2009

Funderburk Sarah F, Shatkina Liubov, Mink Sigrun, Weis Qun, Weg-Remers Susanne, Cato Andrew C B

Abstract excerpt

Polyglutamine (polyQ) stretch amplification in different proteins causes neurodegenerative disease. These proteins form intracellular aggregates thought to be cytotoxic but differ in pathology and tissue specificity. Here, we demonstrate that specific sequences outside the polyQ stretch of the human androgen receptor contribute to polyQ pathology. An exchange of two N-terminal serine phosphorylation residues to...

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Identifiers

PMID: 18289734
DOI: 10.1016/j.neurobiolaging.2007.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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