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Article

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.

The Journal of biological chemistry - 27 Feb 2004

Thomas Monzy, Dadgar Nahid, Aphale Abhishek, Harrell Jennifer M, Kunkel Robin, Pratt William B, Lieberman Andrew P

Abstract excerpt

Kennedy's disease is a degenerative disorder of motor neurons caused by the expansion of a glutamine tract near the amino terminus of the androgen receptor (AR). Ligand binding to the receptor is associated with several post-translational modifications, but it is poorly understood whether these a...

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Source

Identifiers

PMID: 14670946
DOI: 10.1074/jbc.M311761200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14670946-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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