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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

6 Mar 2025

Abstract excerpt

The HIV-1 TAR RNA plays key roles in viral genome architecture, transcription and replication. Previous structural analyses focused on its upper stem loop, which has served as a paradigm to study RNA structural dynamics. However, an imperfectly paired lower stem immediately abuts and stacks with the upper half, both of which are required for efficient HIV replication. Here, we report crystal structures of the...

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PMID: 40050622
DOI: 10.1038/s41467-025-57519-w

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