Article

Analysis of the effect of HIV-1 subtype-specific Tat polymorphisms on Tat-TAR interaction

2024-05-15

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction: </bold>HIV Tat is responsible for HIV replication activation and interacts with the TAR RNA element for its function. Genetic polymorphisms in the Tat sequence can affect the interaction between Tat and TAR. Previous studies, focusing on HIV subtypes B and C, found that substitutions such as C31S, R57S, and Q63E can alter the binding conformations of Tat and TAR. How...

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Literature Corpus work: c944b8d4-1784-546d-9490-e7702c2ed0d8
DOI: 10.21203/rs.3.rs-4371618/v1

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