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Article

How many genes underlie the occurrence of common complex diseases in the population?

International journal of epidemiology - 1 Oct 2005

Yang Quanhe, Khoury Muin J, Friedman Jm, Little Julian, Flanders W Dana

Abstract excerpt

BACKGROUND: Most common human diseases are due to complex interactions among multiple genetic variants and environmental risk factors. There is debate over whether variants of a relatively small number of genes, each with weak or modest individual effects, account for a large proportion of common diseases in the population, or whether a large number of rare variants with large effects underlie genetic...

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PMID: 16043441
DOI: 10.1093/ije/dyi130

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