Article
BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.
Cancer research - 15 Aug 2003
Chan Tsun L, Zhao Wei, Leung Suet Y, Yuen Siu T
Abstract excerpt
Colorectal cancer is believed to progress through an adenoma-carcinoma sequence. However, recent evidence increasingly supports the existence of an alternative route for colorectal carcinogenesis through serrated polyps, a group that encompasses a morphological spectrum, including hyperplastic polyp (HP), admixed hyperplastic polyp/adenoma (HP/AD), and serrated adenoma (SA; the latter two manifest epithelial...
Topics
- Adenoma
- Colonic Polyps
- Colorectal Neoplasms
- Female
- Genes, ras
- Humans
- Hyperplasia
- Male
- Mutation
- Oncogene Proteins
- Proto-Oncogene Proteins B-raf