Article
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
Human molecular genetics - 1 May 2005
Xu Jin, Zhong Nan, Wang Haoyong, Elias Joshua E, Kim Christina Y, Woldman Irina, Pifl Christian, Gygi Steven P, Geula Changiz, Yankner Bruce A
Abstract excerpt
Mutations in the DJ-1 gene cause early-onset autosomal recessive Parkinson's disease (PD), although the role of DJ-1 in the degeneration of dopaminergic neurons is unresolved. Here we show that the major interacting-proteins with DJ-1 in dopaminergic neuronal cells are the nuclear proteins p54nrb and pyrimidine tract-binding protein-associated splicing factor (PSF), two multifunctional regulators of transcription...
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