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Article

A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction

26 Feb 2023

Abstract excerpt

Several studies have identified mutations in neuroprotective genes in a few cases of Parkinson's disease (PD); however, the role of alternative splicing changes in PD remains unelucidated. Based on the transcriptome analysis of substantia nigra (SN) tissues obtained from PD cases and age-matched healthy controls, we identified a novel alternative splicing variant of DJ-1, lacking exon 6 (DJ-1ΔE6), frequently...

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PMID: 36915530
DOI: 10.1016/j.heliyon.2023.e14039

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