Article
LDL-activated p38 in endothelial cells is mediated by Ras.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2001
Zhu Y, Liao H, Wang N, Ma K S, Verna L K, Shyy J Y, Chien S, Stemerman M B
Abstract excerpt
Endothelial dysfunction is a major atherogenic proinflammatory event. LDL causes the activation and phenotypic changes of cultured vascular endothelial cells (ECs). We previously reported that LDL activates c-Jun and AP-1 in ECs. In this study, we demonstrated that p38-ATF-2 is activated by LDL in human ECs and that this activation is mediated by Ras. When ECs are incubated with LDL in pathophysiological...
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