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Article

Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1

11 Nov 2014

Abstract excerpt

AIMS: The MEK5/Erk5 pathway mediates beneficial effects of laminar flow, a major physiological factor preventing vascular dysfunction. Forced Erk5 activation induces a protective phenotype in endothelial cell (EC) that is associated with a dramatically decreased migration capacity of those cells. Transcriptional profiling identified the Krüppel-like transcription factors KLF2 and KLF4 as central mediators of...

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PMID: 25388666
DOI: 10.1093/cvr/cvu236

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