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Article

Conditional alleles for activation and inactivation of the mouse Rx homeobox gene.

Genesis (New York, N.Y. : 2000) - 1 Apr 2005

Voronina Vera A, Kozlov Serguei, Mathers Peter H, Lewandoski Mark

Abstract excerpt

The Rx homeobox gene is a transcriptional regulator indispensable for development of the eye and ventral forebrain. Rx-null homozygotes lack optic pits, which are the earliest ocular structures. To study the roles Rx may play at various stages of eye and brain development, we generated an allelic series at the Rx locus. The targeted allele, Rx(neo), is a severely hypomorphic or null allele. This Rx(neo) allele is...

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Identifiers

PMID: 15789424
DOI: 10.1002/gene.20109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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