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Article

Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.

PloS one - 21 Jul 2010

Béby Francis, Housset Michael, Fossat Nicolas, Le Greneur Coralie, Flamant Frédéric, Godement Pierre, Lamonerie Thomas

Abstract excerpt

BACKGROUND: Many developmental genes are still active in specific tissues after development is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain and head development. In adult mouse, Otx2 is strongly expressed in the retina. Mutations of this gene in humans have been linked to severe ocular malformation and retinal diseases. It is, therefore, important to explore its...

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Identifiers

PMID: 20657788
DOI: 10.1371/journal.pone.0011673
PMCID: PMC2908139

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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