Article
Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice.
Genesis (New York, N.Y. : 2000) - 1 Jan 2000
Zhang L, Mathers P H, Jamrich M
Abstract excerpt
Rx plays a critical role in eye formation. Targeted elimination of Rx results in embryos that do not develop eyes. In this study, we have investigated the expression of Otx2, Six3, and Pax6 in Rx deficient embryos. We find that these genes show normal activation in the anterior neural plate in Rx-/- embryos, but they are not upregulated in the area of the neural plate that would form the primordium of the optic...
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