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Article

Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans.

Yeast (Chichester, England) - 1 Mar 2005

Jung Won Hee, Warn Peter, Ragni Enrico, Popolo Laura, Nunn Christopher D, Turner Michael P, Stateva Lubomira

Abstract excerpt

A role for the cAMP-dependent pathway in regulation of the cell wall in the model yeast Saccharomyces cerevisiae has recently been demonstrated. In this study we report the results of a phenotypic analysis of a Candida albicans mutant, characterized by a constitutive activation of the cAMP pathway due to deletion of PDE2, the gene encoding the high cAMP-affinity phosphodiesterase. Unlike wild-type strains, this...

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PMID: 15789349
DOI: 10.1002/yea.1199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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