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Article

UDP-glucose 4, 6-dehydratase activity plays an important role in maintaining cell wall integrity and virulence of Candida albicans.

PLoS pathogens - 1 Nov 2011

Sen Manimala, Shah Bhavin, Rakshit Srabanti, Singh Vijender, Padmanabhan Bhavna, Ponnusamy Manikandan, Pari Koteppa, Vishwakarma Ram, Nandi Dipankar, Sadhale Parag P

Abstract excerpt

Candida albicans, a human fungal pathogen, undergoes morphogenetic changes that are associated with virulence. We report here that GAL102 in C. albicans encodes a homolog of dTDP-glucose 4,6-dehydratase, an enzyme that affects cell wall properties as well as virulence of many pathogenic bacteria. We found that GAL102 deletion leads to greater sensitivity to antifungal drugs and cell wall destabilizing agents like...

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PMID: 22114559
DOI: 10.1371/journal.ppat.1002384
PMCID: PMC3219719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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