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Transcriptome profiling of a Saccharomyces cerevisiae mutant with a constitutively activated Ras/cAMP pathway.

Physiological genomics - 16 Dec 2003

Jones D L, Petty J, Hoyle D C, Hayes A, Ragni E, Popolo L, Oliver S G, Stateva L I

Abstract excerpt

Often changes in gene expression levels have been considered significant only when above/below some arbitrarily chosen threshold. We investigated the effect of applying a purely statistical approach to microarray analysis and demonstrated that small changes in gene expression have biological significance. Whole genome microarray analysis of a pde2Delta mutant, constructed in the Saccharomyces cerevisiae reference...

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PMID: 14570984
DOI: 10.1152/physiolgenomics.00139.2003

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