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Article

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2005

Ivey F Douglas, Hoffman Charles S

Abstract excerpt

G protein-mediated signaling is implicated in yeast and fungal cAMP pathways. By two-hybrid screens and pull-down experiments, we show that the fission yeast Gpa2 Galpha binds an N-terminal domain of adenylate cyclase, comprising a moderately conserved sequence within a region otherwise poorly related to other fungal adenylate cyclases. Overexpressing this domain in yeast perturbs cAMP signaling, which is...

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Identifiers

PMID: 15831585
DOI: 10.1073/pnas.0502270102
PMCID: PMC1087962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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