Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci.

Genes and immunity - 1 Jun 2005

Natividad A, Wilson J, Koch O, Holland M J, Rockett K, Faal N, Jallow O, Joof H M, Burton M J, Alexander N D E, Kwiatkowski D P, Mabey D C W, Bailey R L

Abstract excerpt

Experimental evidence implicates interferon gamma (IFNgamma) in protection from and resolution of chlamydial infection. Conversely, interleukin 10 (IL10) is associated with susceptibility and persistence of infection and pathology. We studied genetic variation within the IL10 and IFNgamma loci in relation to the risk of developing severe complications of human ocular Chlamydia trachomatis infection. A total of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cicatrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gambia

Share to Haplotypes

Share to Interferon-gamma

Share to Interleukin-10

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 15789056
DOI: 10.1038/sj.gene.6364182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci.PMID 15789056Read ↗

Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.Semantic proximity Read ↗

Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians.Semantic proximity Read ↗

Polymorphisms in Candidate Genes and Risk of Scarring Trachoma in aChlamydia trachomatis–Endemic PopulationSemantic proximity Read ↗

Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.Semantic proximity Read ↗

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation.Semantic proximity Read ↗

miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease.Semantic proximity Read ↗

Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.Semantic proximity Read ↗

A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection.Semantic proximity Read ↗

Conjunctival MicroRNA Expression in Inflammatory Trachomatous ScarringSemantic proximity Read ↗

Sequence based HLA-DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in The Gambia.Semantic proximity Read ↗

Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.Semantic proximity Read ↗

Conjunctival microbiome-host responses are associated with impaired epithelial cell health in both early and late stages of trachomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.