Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.

doi:10.1038/srep17447

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Article

Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.

Scientific reports - 30 Nov 2015

Roberts Chrissy h, Franklin Christopher S, Makalo Pateh, Joof Hassan, Sarr Isatou, Mahdi Olaimatu S, Sillah Ansumana, Bah Momodou, Payne Felicity, Jeffreys Anna E, Bottomley William, Natividad Angels, Molina-Gonzalez Sandra, Burr Sarah E, Preston Mark, Kwiatkowski Dominic, Rockett Kirk A, Clark Taane G, Burton Matthew J, Mabey David C W, Bailey Robin, Barroso Inês, Holland Martin J

Abstract excerpt

Chlamydia trachomatis causes both trachoma and sexually transmitted infections. These diseases have similar pathology and potentially similar genetic predisposing factors. We aimed to identify polymorphisms and pathways associated with pathological sequelae of ocular Chlamydia trachomatis infections in The Gambia. We report a discovery phase genome-wide association study (GWAS) of scarring trachoma (1090 cases,...

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PMID: 26616738
DOI: 10.1038/srep17447
PMCID: PMC4663496

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PREX2

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