Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.

Abstract excerpt

Neuronal migration and lamina-specific primary afferent projections are crucial for establishing spinal cord circuits, but the underlying mechanisms are poorly understood. Here, we report that in mice lacking Dcc (deleted in colorectal cancer), some early-born neurons could not migrate ventrally in the spinal cord. Conversely, forced expression of Dcc caused ventral migration and prevented dorsolateral migration...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Adhesion Molecules
• Share to Cell Movement