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Article

Netrin-1 Is a Chemorepellent for Oligodendrocyte Precursor Cells in the Embryonic Spinal Cord

1 May 2003

Abstract excerpt

Netrin-1, secreted by floor plate cells, orients axon extension in relation to the ventral midline of the embryonic spinal cord. Oligodendrocyte precursor (OP) cells are born close to the ventral midline and migrate away from the floor plate. Here we show that OP cells, identified by expression of the platelet-derived growth factor alpha receptor, express the netrin receptors dcc and unc5h1 but do not express...

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PMID: 12736344
DOI: 10.1523/jneurosci.23-09-03735.2003

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Related research

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Netrin-1 Is a Chemorepellent for Oligodendrocyte Precursor Cells in the Embryonic Spinal CordPMID 12736344Read ↗

Netrin-1 is required for the normal development of spinal cord oligodendrocytes.Semantic proximity Read ↗

Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.Semantic proximity Read ↗

Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction.Semantic proximity Read ↗

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.Semantic proximity Read ↗

Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.Semantic proximity Read ↗

Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord.Semantic proximity Read ↗

Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons.Semantic proximity Read ↗

Axon tracts correlate with netrin-1a expression in the zebrafish embryo.Semantic proximity Read ↗

Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration.Semantic proximity Read ↗

RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.Semantic proximity Read ↗

Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons.Semantic proximity Read ↗

Prox1 Inhibits Proliferation and Is Required for Differentiation of the Oligodendrocyte Cell Lineage in the MouseSemantic proximity Read ↗

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