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Article

Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration.

Molecular and cellular neurosciences - 1 Aug 2009

Marcos Séverine, Backer Stéphanie, Causeret Frédéric, Tessier-Lavigne Marc, Bloch-Gallego Evelyne

Abstract excerpt

Netrin-1 was previously shown to be required for the tangential migration and survival of neurons that will form the inferior olivary nucleus (ION). Surprisingly, the compared analysis of mutant mice lacking either Netrin-1 or its major receptor DCC reveals striking phenotypic differences besides common features. Although ectopic stops of ION cell bodies occur in the same positions along the migratory stream in...

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Source

Identifiers

PMID: 19409494
DOI: 10.1016/j.mcn.2009.04.008

Genes

DCC

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