Article
A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.
Neurobiology of aging - 1 Oct 2015
Ferrari Raffaele, Grassi Mario, Salvi Erika, Borroni Barbara, Palluzzi Fernando, Pepe Daniele, D'Avila Francesca, Padovani Alessandro, Archetti Silvana, Rainero Innocenzo, Rubino Elisa, Pinessi Lorenzo, Benussi Luisa, Binetti Giuliano, Ghidoni Roberta, Galimberti Daniela, Scarpini Elio, Serpente Maria, Rossi Giacomina, Giaccone Giorgio, Tagliavini Fabrizio, Nacmias Benedetta, Piaceri Irene, Bagnoli Silvia, Bruni Amalia C, Maletta Raffaele G, Bernardi Livia, Postiglione Alfredo, Milan Graziella, Franceschi Massimo, Puca Annibale A, Novelli Valeria, Barlassina Cristina, Glorioso Nicola, Manunta Paolo, Singleton Andrew, Cusi Daniele, Hardy John, Momeni Parastoo
Abstract excerpt
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. We identified 2 novel potential loci for FTD. Suggestive SNPs reached p-values ∼10(-7) and odds...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.