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Article

The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study.

EBioMedicine - 1 Jul 2017

Kuenzig M Ellen, Yim Jeff, Coward Stephanie, Eksteen Bertus, Seow Cynthia H, Barnabe Cheryl, Barkema Herman W, Silverberg Mark S, Lakatos Peter L, Beck Paul L, Fedorak Richard, Dieleman Levinus A, Madsen Karen, Panaccione Remo, Ghosh Subrata, Kaplan Gilaad G

Abstract excerpt

BACKGROUND: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). METHODS: Phase 1: MEDLINE and EMBASE were searched for studies (n=18) providing data on NOD2 and smoking in Crohn's disease. NOD2-smoking interactions were estimated using odds ratios (ORs)...

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Identifiers

PMID: 28668336
DOI: 10.1016/j.ebiom.2017.06.012
PMCID: PMC5514403

Genes

NOD2

Variants

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