Article
The 3020insC allele of NOD2 predisposes to early-onset breast cancer.
Breast cancer research and treatment - 1 Jan 2005
Huzarski Tomasz, Lener Marcin, Domagała Wenancjusz, Gronwald Jacek, Byrski Tomasz, Kurzawski Grzegorz, Suchy Janina, Chosia Maria, Woyton Janusz, Ucinski Michał, Narod Steven A, Lubiński Jan
Abstract excerpt
The NOD2 gene has been associated with susceptibility to Crohn's disease, and more recently with carcinoma of the colon as well. NOD2 is involved in the inflammatory response and the activation of the NFkB pathway. The range of cancer types associated with NOD2 has not been well studied. The 3020insC allele results in a truncated NOD2 protein and is present in approximately 7% of the population. We studied a...
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