Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells

24 Apr 2008

Abstract excerpt

A number of proteins involved in cell growth control, including members of the Ras family of GTPases, are modified at their C terminus by a three-step posttranslational process termed prenylation. The enzyme isoprenylcysteine carboxylmethyl-transferase (Icmt) catalyzes the last step in this process, and genetic and pharmacological suppression of Icmt activity significantly impacts on cell growth and oncogenesis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Histone Deacetylase Inhibitors Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18434300
DOI: 10.1074/jbc.m801855200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer CellsPMID 18434300Read ↗

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.Semantic proximity Read ↗

Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growthSemantic proximity Read ↗

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethalitySemantic proximity Read ↗

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.Semantic proximity Read ↗

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.Semantic proximity Read ↗

A Role for Rac3 GTPase in the Regulation of AutophagySemantic proximity Read ↗

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.Semantic proximity Read ↗

Farnesyltransferase inhibitors: potential role in the treatment of cancer.Semantic proximity Read ↗

Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS productionSemantic proximity Read ↗

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.Semantic proximity Read ↗

Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.Semantic proximity Read ↗

Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.