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Article

CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions.

The Journal of biological chemistry - 1 Nov 2023

Tennakoon Mithila, Thotamune Waruna, Payton John L, Karunarathne Ajith

Abstract excerpt

Prenylation is an irreversible post-translational modification that supports membrane interactions of proteins involved in various cellular processes, including migration, proliferation, and survival. Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative diseases. Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during...

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Identifiers

PMID: 37739036
DOI: 10.1016/j.jbc.2023.105269
PMCID: PMC10590752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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