Article
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Molecular cell - 23 Dec 2011
Yang Jing, Kulkarni Kiran, Manolaridis Ioannis, Zhang Ziguo, Dodd Roger B, Mas-Droux Corine, Barford David
Abstract excerpt
The posttranslational modification of C-terminal CAAX motifs in proteins such as Ras, most Rho GTPases, and G protein γ subunits, plays an essential role in determining their subcellular localization and correct biological function. An integral membrane methyltransferase, isoprenylcysteine carboxyl methyltransferase (ICMT), catalyzes the final step of CAAX processing after prenylation of the cysteine residue and...
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