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Article

Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment.

American journal of physiology. Cell physiology - 1 Nov 2010

Lee Ryan S, Tikunova Svetlana B, Kline Kristopher P, Zot Henry G, Hasbun Javier E, Minh Nguyen Van, Swartz Darl R, Rall Jack A, Davis Jonathan P

Abstract excerpt

To investigate effects of altering troponin (Tn)C Ca(2+) binding properties on rate of skeletal muscle contraction, we generated three mutant TnCs with increased or decreased Ca(2+) sensitivities. Ca(2+) binding properties of the regulatory domain of TnC within the Tn complex were characterized by following the fluorescence of an IAANS probe attached onto the endogenous Cys(99) residue of TnC. Compared with...

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Identifiers

PMID: 20702687
DOI: 10.1152/ajpcell.00491.2009
PMCID: PMC2980305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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