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Article

Single-molecule PCR: an artifact-free PCR approach for the analysis of somatic mutations.

Expert review of molecular diagnostics - 1 Sept 2005

Kraytsberg Yevgenya, Khrapko Konstantin

Abstract excerpt

A critical review of the clone-by-clone approach to the analysis of complex spectra of somatic mutations is presented. The study of a priori unknown somatic mutations requires painstaking analysis of complex mixtures of multiple mutant and non-mutant DNA molecules. If mutant fractions are sufficiently high, these mixtures can be dissected by the cloning of individual DNA molecules and scanning of the individual...

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PMID: 16149882
DOI: 10.1586/14737159.5.5.809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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