Article
Quantification of random mutations in the mitochondrial genome.
Methods (San Diego, Calif.) - 1 Dec 2008
Vermulst Marc, Bielas Jason H, Loeb Lawrence A
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations contribute to the pathology of a number of age-related disorders, including Parkinson disease [A. Bender et al., Nat. Genet. 38 (2006) 515,Y. Kraytsberg et al., Nat. Genet. 38 (2006) 518], muscle-wasting [J. Wanagat, Z. Cao, P. Pathare, J.M. Aiken, FASEB J. 15 (2001) 322], and the metastatic potential of cancers [K. Ishikawa et al., Science 320 (2008) 661]. The impact of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.