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Article

Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.

PloS one - 19 Nov 2009

Cironi Luisa, Provero Paolo, Riggi Nicola, Janiszewska Michalina, Suva Domizio, Suva Mario-Luca, Kindler Vincent, Stamenkovic Ivan

Abstract excerpt

BACKGROUND: A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripotent stem cells. The resulting fusion protein ha...

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Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Mesenchymal Stem Cells

Share to Oncogene Proteins, Fusion

Share to Transcription, Genetic

Share to Translocation, Genetic

Source

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Identifiers

PMID: 19936258
DOI: 10.1371/journal.pone.0007904
PMCID: PMC2775947

Genes

IGF2
BCL2
SSX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19936258-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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