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The <i>SPANX</i> gene family of cancer/testis-specific antigens: Rapid evolution and amplification in African great apes and hominids

18 Feb 2004

Abstract excerpt

Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antigens that are potential targets for cancer immunotherapy. These highly similar paralogous genes cluster on the X chromosome at Xq27. We isolated and sequenced primate genomic clones homologous to human SPANX. Analysis...

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PMID: 14973187
DOI: 10.1073/pnas.0308532100

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