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Article

Synovial Sarcoma Is a Stem Cell Malignancy

1 Jun 2010

Abstract excerpt

Synovial sarcoma (SS) is a malignant soft tissue tumor characterized by its unique t(X;18)(p11;q11) chromosomal translocation leading to the formation of the SS18-SSX fusion gene. The resulting fusion protein product is considered to play as an aberrant transcription factor and transform target cells by perturbing their gene expression program. However, the cellular origin of SS is highly debated. We herein...

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PMID: 20518020
DOI: 10.1002/stem.452

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