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Concise Review: Cancer/Testis Antigens, Stem Cells, and Cancer

30 Nov 2006

Abstract excerpt

In the multistep process of cancer development, the concept that cancer stem cells are derived from normal stem cells that have gradually accumulated various genetic and epigenetic defects is gaining strong evidence. A number of investigations have identified molecular markers that, under normal conditions, are responsible for stem cell homeostasis but are also expressed in tumor "stem cell-like" subpopulations....

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Identifiers

PMID: 17138959
DOI: 10.1634/stemcells.2006-0469

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