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Article

CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus.

Cancer research - 15 Mar 2005

Hernández Luis, Beà Silvia, Pinyol Magda, Ott German, Katzenberger Tiemo, Rosenwald Andreas, Bosch Francesc, López-Guillermo Armando, Delabie Jan, Colomer Dolors, Montserrat Emili, Campo Elías

Abstract excerpt

Amplification of 12q13 locus occurs in some mantle cell lymphomas (MCL), potentially involving CDK4 and MDM2 genes. To determine the role of these genes in MCL, we have examined their gene status and expression and their relationship to INK4a/ARF and p53 gene aberrations in 69 tumors. Increased CDK4 gene copy number was detected in 4 of 19 (21%) highly proliferative blastoid variants and was associated with mRNA...

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Source

Identifiers

PMID: 15781632
DOI: 10.1158/0008-5472.CAN-04-1526

Genes

CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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