Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

doi:10.1038/sj.leu.2401090

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Article

Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

Leukemia - 1 Aug 1998

Grønbaek K, Nedergaard T, Andersen M K, thor Straten P, Guldberg P, Møller P, Zeuthen J, Ebbe Hansen N, Hou-Jensen K, Ralfkiaer E

Abstract excerpt

Mantle cell lymphomas (MCL) are morphologically and immunophenotypically distinctive lymphoid neoplasms characterised by overexpression of cyclin D1. Recent studies have suggested that co-operating aberrations of cell cycle associated genes may provide a growth advantage to a tumour. To address t...

Topics

Adult
Aged
Aged, 80 and over
Cell Cycle Proteins
Cyclin D1
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Female
Genes, cdc
Genotype
Humans
Lymphoma, Non-Hodgkin

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Phenotype

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 9697882
DOI: 10.1038/sj.leu.2401090

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9697882-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.