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Article

Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

Leukemia - 1 Aug 1998

Grønbaek K, Nedergaard T, Andersen M K, thor Straten P, Guldberg P, Møller P, Zeuthen J, Ebbe Hansen N, Hou-Jensen K, Ralfkiaer E

Abstract excerpt

Mantle cell lymphomas (MCL) are morphologically and immunophenotypically distinctive lymphoid neoplasms characterised by overexpression of cyclin D1. Recent studies have suggested that co-operating aberrations of cell cycle associated genes may provide a growth advantage to a tumour. To address this issue further, we investigated five typical and three aggressive (blastoid) MCL for alterations in the cell cycle...

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Identifiers

PMID: 9697882
DOI: 10.1038/sj.leu.2401090

Genes

CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.PMID 9697882Read ↗

Pathogenesis of Mantle-Cell Lymphoma: All Oncogenic Roads Lead to Dysregulation of Cell Cycle and DNA Damage Response PathwaysSemantic proximity Read ↗

Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [<i>p16</i>(<i>INK4a</i>), <i>p15</i>(<i>INK4b</i>), <i>p14</i>(<i>ARF</i>)] in mantle cell lymphomaSemantic proximity Read ↗

Clinical, Morphologic, Phenotypic, and Genetic Evidence of Cyclin D1-positive Diffuse Large B-cell Lymphomas With CYCLIN D1 Gene RearrangementsSemantic proximity Read ↗

Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.Semantic proximity Read ↗

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profilingSemantic proximity Read ↗

[Research advance of p53 gene in mantle cell lymphoma].Semantic proximity Read ↗

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Specific Secondary Genetic Alterations in Mantle Cell Lymphoma Provide Prognostic Information Independent of the Gene Expression–Based Proliferation SignatureSemantic proximity Read ↗

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.Semantic proximity Read ↗

Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.Semantic proximity Read ↗

CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphomaSemantic proximity Read ↗

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