Article
Misbehaviour of XIST RNA in breast cancer cells.
PloS one - 1 Jan 2009
Sirchia Silvia M, Tabano Silvia, Monti Laura, Recalcati Maria P, Gariboldi Manuela, Grati Francesca R, Porta Giovanni, Finelli Palma, Radice Paolo, Miozzo Monica
Abstract excerpt
A role of X chromosome inactivation process in the development of breast cancer have been suggested. In particular, the relationship between the breast cancer predisposing gene BRCA1 and XIST, the main mediator of X chromosome inactivation, has been intensely investigated, but still remains controversial. We investigated this topic by assessing XIST behaviour in different groups of breast carcinomas and in a...
Topics
- BRCA1 Protein
- Breast Neoplasms
- Cell Line
- Cell Line, Tumor
- Chromosomes, Human, X
- Fluorescent Antibody Technique, Indirect
- Genotype
- Humans
- In Situ Hybridization, Fluorescence
- RNA Interference
- RNA, Long Noncoding
- RNA, Untranslated
- Reverse Transcriptase Polymerase Chain Reaction