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Article

Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1.

Journal of the National Cancer Institute - 5 Nov 2008

Lose Felicity, Duffy David L, Kay Graham F, Kedda Mary A, Spurdle Amanda B

Abstract excerpt

BACKGROUND: X chromosome inactivation, which silences gene expression from one of the two X chromosomes in females, is usually random. Skewed X inactivation has been implicated in both the expression and the suppression of X-linked disease phenotypes and has been reported to occur more frequently in breast and ovarian cancer patients, including BRCA1 or BRCA2 mutation carriers, than in control subjects. METHODS:...

Read the complete abstract on PubMed

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Share to Chromosomes, Human, X
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA2

Share to Genes, X-Linked

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Share to Proportional Hazards Models

Share to Receptors, Androgen

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Source

Identifiers

PMID: 18957670
DOI: 10.1093/jnci/djn345

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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