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Article

X chromosome inactivation pattern in BRCA gene mutation carriers.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2013

Manoukian Siranoush, Verderio Paolo, Tabano Silvia, Colapietro Patrizia, Pizzamiglio Sara, Grati Francesca R, Calvello Mariarosaria, Peissel Bernard, Burn John, Pensotti Valeria, Allemani Claudia, Sirchia Silva M, Radice Paolo, Miozzo Monica

Abstract excerpt

An association of preferential X chromosome inactivation (XCI) with BRCA gene status and breast/ovarian cancer risk has been reported. We evaluated XCI in a large group of BRCA mutation carriers compared to non-carriers and investigated associations between preferential XCI (⩾90:10) and age, mutated gene, cancer development and chemotherapy. XCI was analysed by human androgen receptor (HUMARA) assay and...

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Source

Identifiers

PMID: 23146957
DOI: 10.1016/j.ejca.2012.10.013

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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