Article
Chromatin structure analysis of the mouse Xist locus.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999
McCabe V, Formstone E J, O'Neill L P, Turner B M, Brockdorff N
Abstract excerpt
The Xist gene is expressed exclusively from the inactive X chromosome and plays a central role in regulating X chromosome inactivation. Here we describe experiments aimed at defining the extent of the active chromatin domain of the expressed Xist allele. By using an allele-specific general DNaseI sensitivity assay we show that there is preferential digestion of the expressed allele at sites within the transcribed...
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